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Kapil Bhalla Selected Research

Hydroxamic Acids (Hydroxamic Acid)

10/2008Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.
10/2008Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
8/2006A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies.
2/2005Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
12/2004Histone deacetylase inhibitors in myelodysplastic syndrome.
10/2003Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.
8/2003Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

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Kapil Bhalla Research Topics

Disease

24Leukemia
04/2022 - 05/2002
20Neoplasms (Cancer)
01/2022 - 04/2003
17Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
04/2022 - 04/2004
16BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
10/2008 - 10/2002
5Breast Neoplasms (Breast Cancer)
07/2014 - 01/2003
5Blast Crisis (Blast Phase)
03/2006 - 10/2002
4Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2020 - 12/2004
4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
04/2007 - 03/2006
3Hematologic Neoplasms (Hematological Malignancy)
04/2022 - 08/2006
3Philadelphia Chromosome
11/2007 - 06/2006
2Vitamin D Deficiency
09/2021 - 04/2021
2Anemia
07/2020 - 03/2019
2Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2019 - 12/2010
2Genetic Translocation (Chromosomal Translocation)
06/2008 - 12/2002
2Colonic Neoplasms (Colon Cancer)
09/2004 - 04/2003
1Vomiting
04/2022
1Gastritis
04/2022
1Asthma (Bronchial Asthma)
04/2022
1Metabolic Bone Diseases (Osteopenia)
09/2021
1Cerebral Palsy (Spastic Diplegia)
09/2021
1Epilepsy (Aura)
09/2021
1Viral Pneumonia
04/2021
1Bacterial Pneumonia
04/2021
1Pneumonia (Pneumonitis)
04/2021
1Chronic Disease (Chronic Diseases)
01/2021
1COVID-19
01/2021
1Septic Shock (Toxic Shock Syndrome)
11/2020
1Vitamin B 12 Deficiency (Vitamin B12 Deficiency)
07/2020
1Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
07/2020
1Iron-Deficiency Anemia (Anemia, Iron Deficiency)
07/2020
1Poisoning
03/2020
1Brain Diseases (Brain Disorder)
03/2020
1Hypoglycemia (Reactive Hypoglycemia)
03/2020
1Pharyngitis (Sore Throat)
10/2019
1Proteinuria
07/2019
1Nephrotic Syndrome (Syndrome, Nephrotic)
07/2019
1Celiac Disease (Celiac Sprue)
03/2019

Drug/Important Bio-Agent (IBA)

16Histone Deacetylase InhibitorsIBA
07/2014 - 04/2003
15Imatinib Mesylate (Gleevec)FDA Link
01/2019 - 10/2002
14Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2003
7Pharmaceutical PreparationsIBA
04/2022 - 08/2003
7VorinostatFDA Link
07/2014 - 04/2003
7LAQ824IBA
10/2008 - 08/2003
7Hydroxamic Acids (Hydroxamic Acid)IBA
10/2008 - 08/2003
7PanobinostatIBA
10/2008 - 02/2005
5LigandsIBA
01/2019 - 05/2002
5Histones (Histone)IBA
10/2012 - 01/2004
5Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2008 - 05/2004
5Phosphotransferases (Kinase)IBA
04/2007 - 05/2004
4DNA (Deoxyribonucleic Acid)IBA
10/2020 - 10/2008
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2019 - 05/2002
4Histone Deacetylases (Histone Deacetylase)IBA
10/2008 - 08/2003
4tanespimycin (17AAG)IBA
10/2008 - 10/2002
4Tyrosine Kinase InhibitorsIBA
10/2006 - 11/2002
3Anti-Bacterial Agents (Antibiotics)IBA
04/2021 - 10/2019
3Trastuzumab (Herceptin)FDA Link
07/2014 - 10/2003
3TubulinIBA
07/2014 - 04/2003
3Dasatinib (BMS 354825)FDA Link
05/2009 - 10/2006
3bcr-abl Fusion ProteinsIBA
11/2007 - 10/2002
3nilotinibFDA Link
11/2007 - 06/2006
3src-Family KinasesIBA
04/2007 - 10/2002
3Caspase 3 (Caspase-3)IBA
04/2006 - 04/2003
3epothilone B (EPO906)IBA
10/2003 - 01/2003
2Azacitidine (5 Azacytidine)FDA Link
01/2022 - 10/2018
2Vitamin DFDA LinkGeneric
09/2021 - 04/2021
2SteroidsIBA
01/2021 - 01/2018
2Paclitaxel (Taxol)FDA LinkGeneric
07/2014 - 04/2003
2Cytarabine (Cytosar-U)FDA LinkGeneric
01/2012 - 02/2005
2SurvivinIBA
10/2008 - 04/2003
2Molecular Chaperones (Chaperone, Molecular)IBA
06/2008 - 08/2004
2Estrogens (Estrogen)FDA Link
08/2007 - 04/2006
2Small Interfering RNA (siRNA)IBA
12/2006 - 07/2005
2Docetaxel (Taxotere)FDA Link
09/2005 - 10/2003
2midostaurinIBA
08/2004 - 05/2004
2Messenger RNA (mRNA)IBA
11/2003 - 08/2003
2ixabepilone (BMS 247550)FDA Link
04/2003 - 05/2002
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
04/2022
1brusatolIBA
04/2022
1Daunorubicin (Cerubidine)FDA LinkGeneric
04/2022
1Dexamethasone (Maxidex)FDA LinkGeneric
04/2022
1Prednisolone (Predate)FDA LinkGeneric
04/2022
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2022
1PLX51107IBA
01/2022
1UbiquitinIBA
01/2022
1Insulin-Like PeptidesIBA
09/2021
1Insulin-Like Growth Factor I (IGF-1)IBA
09/2021
1Growth Hormone (Somatotropin)IBA
09/2021
1Methylmalonic AcidIBA
07/2020
1HomocysteineIBA
07/2020
1Disulfiram (Antabuse)FDA Link
03/2020
1TabletsIBA
03/2020
1Lenalidomide (CC 5013)FDA Link
01/2020
1RNA Helicases (RNA Helicase)IBA
01/2020
1CreatinineIBA
07/2019
1Immunoglobulin A (IgA)IBA
03/2019

Therapy/Procedure

10Therapeutics
08/2017 - 10/2002
2Immunotherapy
01/2009 - 02/2005
1Blood Transfusion (Blood Transfusions)
07/2020
1Vegetarian Diet (Vegetarianism)
07/2020
1Gluten-Free Diet
03/2019